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Maura Greiser, MD PhD

Dr. Greiser's work centers on investigating cardiac calcium signaling and cellular electrophysiology with a focus on the atria in health and disease. Past and present work has addressed changes specific to Atrial Fibrillation, the most common arrhythmia in men. Dr. Greiser has discovered the concept of “Calcium signaling silencing” in atrial mycocytes as a response to rapid atrial activation. This novel concept is an important adaptive mechanisms after the initiation of atrial fibrillation which protects the atrial myocytes from intracellular calcium overload.

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Dr. Greiser has developed and implemented novel imaging techniques, most of which are designed for investigating calcium signals at high temporal and spatial resolution in isolated atrial myocytes. In addition to the effort to develop new tools he has extensively collaborated with many other investigators to implement these new tools in their ongoing investigations.

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My research focuses on the molecular and cellular mechanisms underlying Atrial Fibrillation. Specifically, I am interested in changes in the intracellular [Ca2+] and  [Na+] homeostasis that underlie arrhythmogenic mechanisms in Atrial Fibrillation. I am using state of the art confocal laser scanning microscopy to image intracellular Ca2+ microdomains in viable atrial myocytes. To address different arrhythmia mechanisms we work with various types of atrial fibrillation animal models. We were the first to characterize significant changes in the intracellular [Na+] homeostasis as a response to rapid atrial activation and current research focusses on the regulatory changes in atrial [Na+] homeostasis during atrial fibrillation.

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To reach out to Dr. Greiser send an email here: MGreiser@som.umaryland.edu

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